Home Drug Guide Oteseconazole

Drug Guide

Generic Name

Oteseconazole

Brand Names Vivjoa

Classification

Therapeutic: Antifungal

Pharmacological: Triazole antifungal

FDA Approved Indications

  • Treatment of recurrent vulvovaginal candidiasis (RVVC) in women of reproductive age who are planning pregnancy or are pregnant

Mechanism of Action

Oteseconazole inhibits the fungal enzyme lanosterol 14α-demethylase, a key enzyme in ergosterol biosynthesis, leading to impaired fungal cell membrane synthesis and cell death.

Dosage and Administration

Adult: 300 mg orally once daily for 3 days; may repeat dose if necessary as per clinician guidance.

Pediatric: Not approved for pediatric use.

Geriatric: No specific dosage adjustment required; use with caution as per general geriatric guidelines.

Renal Impairment: No specific adjustment required.

Hepatic Impairment: Use with caution; no specific dosage adjustment established.

Pharmacokinetics

Absorption: Well absorbed orally, with food not significantly affecting absorption.

Distribution: Extensively distributed; protein binding approximately 99%.

Metabolism: Metabolized primarily via hepatic pathways involving CYP3A4.

Excretion: Primarily excreted in feces, with minor renal excretion.

Half Life: Approximately 56 hours.

Contraindications

  • Hypersensitivity to oteseconazole or other azole antifungals.

Precautions

  • Use with caution in patients with hepatic impairment; monitor liver function tests. Risk of drug interactions due to CYP3A4 metabolism.

Adverse Reactions - Common

  • Nausea (Common)
  • Headache (Common)
  • Vaginal itching or discomfort (Less common)

Adverse Reactions - Serious

  • Hepatic adverse effects, including hepatitis (Rare)
  • Allergic reactions including hypersensitivity (Rare)

Drug-Drug Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) increase oteseconazole levels.
  • CYP3A4 inducers (e.g., rifampin) decrease efficacy.

Drug-Food Interactions

  • None specifically reported, but high-fat meals may slightly alter absorption.

Drug-Herb Interactions

  • No well-documented interactions, but caution with herbal CYP3A4 modulators.

Nursing Implications

Assessment: Monitor for signs of hepatic dysfunction (jaundice, elevated LFTs). Assess for allergic reactions.

Diagnoses:

  • Risk for hepatic injury related to medication use.
  • Knowledge deficit regarding drug therapy.

Implementation: Administer as prescribed, counsel patient on potential side effects and interactions, monitor liver function.

Evaluation: Assess symptom resolution and monitor for adverse effects.

Patient/Family Teaching

  • Take medication as directed, with or without food.
  • Report any unusual symptoms, especially signs of liver problems.
  • Avoid alcohol and hepatotoxic drugs during therapy.
  • Inform about possible drug interactions.

Special Considerations

Black Box Warnings:

  • None specific, but caution due to potential hepatotoxicity.

Genetic Factors: Potential pharmacogenomic variations in CYP3A4 activity may influence drug levels.

Lab Test Interference: None documented.

Overdose Management

Signs/Symptoms: Nausea, vomiting, abdominal pain, elevated liver enzymes.

Treatment: Supportive care; there is no specific antidote. Monitor liver function and provide symptomatic treatment.

Storage and Handling

Storage: Store at room temperature, away from moisture, light, and heat.

Stability: Stable under recommended storage conditions for at least 24 months.

🛡️ 5 Critical Medication Safety Tips for Nurses

1

Triple-Check High-Risk Medications

Always have another nurse verify insulin, heparin, warfarin, and chemotherapy drugs. These "high-alert" medications cause the most serious errors. Check concentration, dose calculation, and pump settings twice.

2

Know Look-Alike, Sound-Alike Drugs

Common mix-ups: hydromorphone/morphine, Celebrex/Celexa, Zyprexa/Zyrtec. Always use BOTH generic and brand names, read labels twice, and use barcode scanning when available. One wrong letter can be fatal.

3

Assess Before AND After Giving Meds

Check vitals before cardiac meds, pain levels before analgesics, and blood glucose before insulin. Always reassess within 30 minutes to evaluate effectiveness and watch for adverse reactions.

4

Watch for Drug Interactions

Common dangerous combinations: warfarin + aspirin (bleeding), ACE inhibitors + potassium (hyperkalemia), digoxin + diuretics (toxicity). Always check drug interactions before administering new medications.

5

Educate Your Patients

Teach patients medication names, purposes, major side effects, and what to report. Informed patients catch errors and improve compliance. Always encourage questions - an educated patient is a safer patient.

⚡ Remember: When in doubt, don't give it out! It's always safer to double-check than regret later.

⚠️ Medical Disclaimer

This drug guide is for educational purposes only and is NOT intended for clinical use. Always consult current prescribing information, healthcare providers, and institutional protocols before administering any medication. Do not use this information for patient care decisions.