Drug Guide
Naftifine Hydrochloride
Classification
Therapeutic: Topical Antifungal and Antiseptic
Pharmacological: Allylamine Antifungal
FDA Approved Indications
- Treatment of topical fungal infections such as tinea corporis, tinea cruris, tinea pedis, and cutaneous candidiasis
Mechanism of Action
Naftifine inhibits squalene epoxidase, an enzyme involved in ergosterol synthesis, leading to disruption of fungal cell membrane synthesis and integrity.
Dosage and Administration
Adult: Apply a thin layer to affected area once or twice daily for the prescribed duration.
Pediatric: Data limited; use as directed by a healthcare provider, typically similar to adult dosing.
Geriatric: No specific dosage adjustments provided; monitor for tolerability.
Renal Impairment: Use with caution; no specific adjustments established.
Hepatic Impairment: Use with caution; no specific adjustments established.
Pharmacokinetics
Absorption: Minimal systemic absorption when used topically.
Distribution: Distributed locally in skin tissues.
Metabolism: Primarily topical; systemic metabolism is minimal.
Excretion: Excreted mainly in skin desquamation; systemic excretion unknown.
Half Life: Not applicable; systemic absorption is minimal.
Contraindications
- Hypersensitivity to naftifine or other allylamines.
Precautions
- Avoid contact with eyes, mucous membranes, or open wounds.
- Use with caution in patients with known sensitivity to topical antifungals.
Adverse Reactions - Common
- Application site redness or irritation (Common)
- Burning sensation at application site (Common)
Adverse Reactions - Serious
- Allergic contact dermatitis (Rare)
- Severe skin reactions (Rare)
Drug-Drug Interactions
- None well documented; consult current sources.
Drug-Food Interactions
- None specific.
Drug-Herb Interactions
- Limited data; avoid concomitant use with other topical agents unless directed.
Nursing Implications
Assessment: Assess for fungal infection sites and possible hypersensitivity.
Diagnoses:
- Impaired skin integrity related to fungal infection or medication side effects.
Implementation: Instruct patient on proper application of medication and hygiene measures.
Evaluation: Monitor effectiveness of infection resolution and watch for adverse skin reactions.
Patient/Family Teaching
- Apply medication as directed, typically once or twice daily.
- Keep the area clean and dry.
- Report any signs of allergic reaction or worsening infection.
- Avoid contact with eyes, mucous membranes, and broken skin.
Special Considerations
Black Box Warnings:
- None
Genetic Factors: Not applicable.
Lab Test Interference: No known interference.
Overdose Management
Signs/Symptoms: Local skin irritation or allergic reactions.
Treatment: Remove applied medication, provide symptomatic relief, and seek medical attention if necessary.
Storage and Handling
Storage: Store at room temperature, away from heat and moisture.
Stability: Stable under recommended conditions; follow manufacturer guidelines.