Drug Guide
Luliconazole
Classification
Therapeutic: Antifungal
Pharmacological: Imidazole antifungal
FDA Approved Indications
- Treatment of tinea corporis, tinea cruris, and tinea pedis (athlete's foot, jock itch, and ringworm)
Mechanism of Action
Luliconazole inhibits fungal cytochrome P450-dependent 14α-demethylase, leading to decreased ergosterol synthesis, which disrupts fungal cell membrane formation and causes cell death.
Dosage and Administration
Adult: Apply a thin layer once daily to the affected area and surrounding skin for 2 weeks (tinea corporis, tinea cruris, tinea pedis).
Pediatric: Not established for pediatric patients; safety and efficacy have not been studied in children.
Geriatric: No specific dosage adjustment required, but monitor for skin irritation.
Renal Impairment: No specific dose adjustment needed.
Hepatic Impairment: No specific dose adjustment needed.
Pharmacokinetics
Absorption: Minimal systemic absorption when used topically.
Distribution: Primarily localized in skin tissues.
Metabolism: Metabolized minimally; some evidence suggests oxidation by skin enzymes.
Excretion: Primarily eliminated via skin; negligible systemic excretion.
Half Life: Not extensively studied due to topicals' localized action.
Contraindications
- Hypersensitivity to luliconazole or any azole antifungal agents.
Precautions
- Use with caution in patients with a history of skin sensitivities. Avoid contact with eyes. Discontinue if signs of irritation or allergic reaction occur.
Adverse Reactions - Common
- Application site burning or stinging (Less common)
- Itching, redness, or skin irritation (Less common)
Adverse Reactions - Serious
- Allergic contact dermatitis (Rare)
- Lack of efficacy or worsening of infection (Reported occasionally)
Drug-Drug Interactions
N/ADrug-Food Interactions
N/ADrug-Herb Interactions
N/ANursing Implications
Assessment: Evaluate affected skin areas prior to and during therapy for signs of infection and adverse reactions.
Diagnoses:
- Impaired skin integrity related to fungal infection or topical medication reactions.
- Risk for skin irritation or allergic response.
Implementation: Instruct the patient to apply the medication as prescribed, avoiding contact with eyes and mucous membranes. Emphasize the importance of completing the full course of therapy.
Evaluation: Assess the skin for resolution of infection and any adverse reactions at follow-up visits.
Patient/Family Teaching
- Apply the medication exactly as directed, usually once daily.
- Keep the affected area clean and dry.
- Report any signs of irritation, increased redness, swelling, or allergic reaction.
- Avoid sharing towels, linens, or personal items to prevent spread or reinfection.
Special Considerations
Black Box Warnings:
- None currently
Genetic Factors: None known to influence drug efficacy or safety.
Lab Test Interference: No known interference with laboratory tests.
Overdose Management
Signs/Symptoms: Local skin irritation, allergic reaction.
Treatment: Remove excess medication, wash the area with soap and water, provide symptomatic treatment for irritation or allergic reactions.
Storage and Handling
Storage: Store at room temperature away from light and moisture.
Stability: Stable under recommended storage conditions for the duration of the shelf life.