Nurses Compass
Drug Guide
Cryptenamine Tannates
Classification
Therapeutic: Antiparasitic, Antiprotozoal
Pharmacological: Tryptophan derivation, Tannate formulation
FDA Approved Indications
- Treatment of intestinal parasitic infections caused by certain protozoa and helminths
Mechanism of Action
Cryptenamine tannates exert antiparasitic effects by interfering with the protozoa's metabolic processes and disrupting their cellular structures, leading to death of the parasites.
Dosage and Administration
Adult: As per clinical guidelines, typically 400 mg once daily for 7-10 days.
Pediatric: Dosage depends on body weight and clinical scenario; generally 10 mg/kg/day divided into two doses for 7-10 days.
Geriatric: Adjust based on renal and hepatic function; close monitoring recommended.
Renal Impairment: Use with caution; dose adjustments may be necessary.
Hepatic Impairment: Use with caution; dosage adjustments may be necessary.
Pharmacokinetics
Absorption: Poorly absorbed from the gastrointestinal tract, primarily acts locally within the intestines.
Distribution: Minimal systemic distribution due to poor absorption.
Metabolism: Metabolized minimally; primarily remains in the intestinal lumen.
Excretion: Excreted mainly in feces.
Half Life: Not well established due to minimal systemic absorption.
Contraindications
- Known hypersensitivity to Cryptenamine tannates or components.
- Use in women who are pregnant or breastfeeding unless benefits outweigh risks.
Precautions
- Monitor renal and hepatic function during therapy.
- Use cautiously in patients with pre-existing gastrointestinal disorders.
Adverse Reactions - Common
- Nausea (Common)
- Vomiting (Common)
- Abdominal discomfort (Common)
Adverse Reactions - Serious
- Gastrointestinal bleeding (Rare)
- Hypersensitivity reactions such as rash or anaphylaxis (Rare)
Drug-Drug Interactions
- Potential interactions with other antiparasitics or medications affecting hepatic enzymes.
Drug-Food Interactions
N/ADrug-Herb Interactions
N/ANursing Implications
Assessment: Assess for duration and severity of parasitic infection, monitor for adverse reactions.
Diagnoses:
- Imbalanced nutrition: less than body requirements related to gastrointestinal discomfort.
- Risk for injury related to adverse reactions.
Implementation: Administer as prescribed, usually with food to minimize gastrointestinal upset.
Evaluation: Assess symptom resolution and monitor for adverse reactions.
Patient/Family Teaching
- Take medication exactly as prescribed.
- Complete the full course of therapy.
- Report any adverse reactions or unusual symptoms.
- Maintain good hygiene to prevent reinfection.
Special Considerations
Black Box Warnings:
- None specified.
Genetic Factors: No known genetic considerations affecting therapy.
Lab Test Interference: Minimal, but monitor stool examinations for parasite clearance.
Overdose Management
Signs/Symptoms: Gastrointestinal disturbances, hypersensitivity reactions.
Treatment: Supportive care, symptomatic treatment, and consider activated charcoal if ingestion is recent.
Storage and Handling
Storage: Store in a cool, dry place, protected from light.
Stability: Stable under recommended storage conditions; check expiration date.