Nurses Compass
Drug Guide
Betazole Hydrochloride
Classification
Therapeutic: Gastric acid secretion stimulant
Pharmacological: Histamine H2 receptor agonist
FDA Approved Indications
- Diagnostic testing of gastric acid secretion
- Treatment of atrophic gastritis
Mechanism of Action
Betazole stimulates gastric acid secretion by directly activating histamine H2 receptors on parietal cells in the stomach, leading to increased gastric acid production.
Dosage and Administration
Adult: Typically, 25-50 mg administered intravenously or intramuscularly; dosage may vary based on clinical indication.
Pediatric: Use is limited; consult specific guidelines or specialist.
Geriatric: Adjust dose based on hepatic function and response.
Renal Impairment: Adjust dose accordingly; monitor for increased sensitivity.
Hepatic Impairment: Dose adjustment may be necessary; use with caution.
Pharmacokinetics
Absorption: Rapid upon intramuscular or intravenous injection.
Distribution: Distributed throughout body tissues.
Metabolism: Metabolized in the liver.
Excretion: Excreted in urine.
Half Life: Approximately 20-25 minutes.
Contraindications
- Hypersensitivity to Betazole or other H2 receptor agonists.
Precautions
- Use with caution in patients with renal or hepatic impairment, or those with gastrointestinal bleeding.
Adverse Reactions - Common
- Nausea (Occasional)
- Headache (Common)
- Gastrointestinal discomfort (Rare)
Adverse Reactions - Serious
- Anaphylactic reactions (Very rare)
- Gastrointestinal bleeding or perforation in sensitive individuals (Rare)
Drug-Drug Interactions
- Caution when combined with other medications affecting gastric acid or histamine pathways.
Drug-Food Interactions
N/ADrug-Herb Interactions
N/ANursing Implications
Assessment: Monitor gastric acidity levels if used diagnostically; observe for adverse reactions.
Diagnoses:
- Risk for allergic reaction
- Impaired gastrointestinal perfusion
Implementation: Administer as prescribed; monitor vital signs and for allergic reactions.
Evaluation: Assess effectiveness in stimulating gastric acid secretion or symptom relief.
Patient/Family Teaching
- Report any allergic reactions such as rash or difficulty breathing.
- Follow proper administration instructions if used at home.
- Inform healthcare providers of all medications.
Special Considerations
Black Box Warnings:
- None at this time.
Genetic Factors: None established.
Lab Test Interference: May affect tests related to gastric acid secretion.
Overdose Management
Signs/Symptoms: Excessive gastric acid production, gastrointestinal discomfort, hypotension.
Treatment: Discontinue drug, provide supportive care, treat symptoms as needed.
Storage and Handling
Storage: Store at room temperature away from moisture and heat.
Stability: Stable under recommended storage conditions.